Detailansicht
The Genetics of Coeliac Disease in Malta
The role of Cytotoxic T-Lymphocyte Associated Antigen 4 in Coeliac Disease Predisposition
ISBN/EAN: 9783838367422
Umbreit-Nr.: 4740539
Sprache:
Englisch
Umfang: 112 S.
Format in cm: 0.7 x 22 x 15
Einband:
kartoniertes Buch
Erschienen am 28.05.2010
Auflage: 1/2010
- Zusatztext
- Two polymorphisms found within the CTLA4 gene were studied amongst a sample of coeliac patients and cord blood DNA samples that acted as the control group. Polymorphisms within the CTLA4 gene have been associated with other autoimmune conditions and the gene plays a very important role in immuno-regulatory function. The coeliac individuals and cord blood samples were genotyped for the -318 C/T and +49 A/G single nucleotide polymorphisms. No association of the single polymorphisms or the combined haplotypes with the coeliac condition was apparent amongst the coeliac patients under study. The -318 C allele and the +49 A allele were in linkage disequilibrium amongst the cord blood samples.
- Autorenportrait
- Dr. Joseph Borg B.Sc M.Sc PhD works as a research scientist at the Laboratory of Molecular Genetics, University of Malta. The work presented here is the first study on complex disease genetics of Coeliac Disease in Malta. It also laid the foundation for a large collection of family patients and relatives with Coeliac Disease.