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Combinatorial Genetic Logic
Multiple transcription factor regulation in synthetic bacterial circuits
ISBN/EAN: 9783838300535
Umbreit-Nr.: 1204688
Sprache:
Englisch
Umfang: 220 S.
Format in cm: 1.4 x 22 x 15
Einband:
kartoniertes Buch
Erschienen am 24.11.2009
- Zusatztext
- This book examines several synthetic transcriptional regulatory circuits in bacteria. Chapter 1 presents a novel technique for shuffling short sequences of regulatory DNA to generate exponential libraries of functional sequences. Chapter 2 introduces a library of combinatorial promoters--genetic logic gates which integrate multiple environmental signals. Chapter 3 examines the role of genetic noise in transcriptional co-regulation using a three-color fluorescent reporter system. Chapter 4 showcases a synthetic circuit for the control of population density in a bacterial growth culture. These examples highlight a quantitative approach for characterizing the logical input functions of prokaryotic genes, focusing on the relationship between combinatorial promoter functions and architectures.
- Autorenportrait
- Spent his youth catching snakes around the swamps and rivers of Tallahassee, Florida. He received a Bachelor's in Physics, Chemistry and Mathematics from New College, the Honors College of Florida. While living in Los Angeles he completed the present work and was awarded a Doctorate in Biology from CalTech. Dr. Cox now resides in Tokyo.