Detailansicht
Drug Transporters
Handbook of Experimental Pharmacology 201
ISBN/EAN: 9783642266454
Umbreit-Nr.: 4428279
Sprache:
Englisch
Umfang: x, 454 S., 13 s/w Illustr., 2 farbige Illustr.
Format in cm:
Einband:
kartoniertes Buch
Erschienen am 25.02.2013
Auflage: 1/2013
- Zusatztext
- It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
- Kurztext
- This book provides a comprehensive overview of key drug transporters.It highlights mechanisms of drug absorption, elimination and drug-drug interactions and discusses the role of drug transporters for drug developmentIncludes supplementary material: sn.pub/extras
- Autorenportrait
- InhaltsangabeFrom the contents.- Preface.- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport