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Parkinson's Disease
Methods and Protocols, Methods in Molecular Medicine 62
ISBN/EAN: 9781617371752
Umbreit-Nr.: 988248
Sprache:
Englisch
Umfang: xi, 317 S., 70 s/w Illustr., 7 farbige Illustr.
Format in cm:
Einband:
kartoniertes Buch
Erschienen am 12.08.2011
Auflage: 1/2011
- Zusatztext
- InhaltsangabePart I. Genetics Point Mutations in the _-Synuclein Gene Abbas Parsian and Joel S. Perlmutter Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis Hiroto Matsumine, Nobutaka Hattori, and Yoshikuni Mizuno Part II. Molecular Pathogenetic Studies Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as _-Synucleinopathies Michel Goedert, Ross Jakes, R. Anthony Crowther, and Maria Grazia Spillantini _Synuclein/Amyloid Interactions Poul Henning Jensen Functional Defect Conferred by the Parkinson's Disease-Causing _-Synuclein (Ala30Pro) Mutation Poul Henning Jensen Molecular Biology of Dopamine-Induced Apoptosis: Possible Implications for Parkinson's Disease Ilan Ziv, Anat Shirvan, Daniel Offen, Ari Barzilai, and Eldad Melamed Animal Models of Induced Apoptotic Death in the Substantia Nigra Tinmarla F. Oo and Robert E. Burke Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigra Tinmarla F. Oo and Robert E. Burke The Role of Nitric Oxide in Parkinson's Disease Serge Przedborski and Ted M. Dawson Oxidative Stress Indices in Parkinson's Disease: Biochemical Determination Moussa B. H. Youdim, Noam Drigues, and Silvia Mandel Part III. Molecular Aspects of Basal Ganglia Function Quantification of Tyrosine Hydroxylase mRNA Hiroshi Ichinose, Tamae Ohye, Takahiro Suzuki, Hidehito Inagaki, and Toshiharu Nagatsu Immunochemical Analysis of Dopamine Transporters in Parkinson's Disease Gary W. Miller and Allan I. Levey Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice: Implications for Parkinson's Disease Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, and Marc G. Caron Transcription Mechanisms for Dopamine Receptor Genes SangHyeon Lee and M. Maral Mouradian Detection of DNA/Protein Interactions in Dopamine Receptor Genes SangHyeon Lee and M. Maral Mouradian In Situ Hybridization on Brain Tissue ClaasHinrich Lammers, Yoshinobu Hara, and M. Maral Mouradian Regulation of Striatal N-Methyl-d-Aspartate Receptor (NMDAR) Function by Phosphorylation of Its Subunits in Parkinsonian Rats Justin D. Oh Part IV. Molecular Therapies Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism Richard Grondin, Zhiming Zhang, Dennis D. Elsberry, Greg A. Gerhardt, and Don M. Gash Grafting Genetically Engineered Cells into the Striatum of NonHuman Primates Krys S. Bankiewicz, Phillip Pivirotto, Rosario Sanchez-Pernaute, and Eugene O. Major Encapsulated Cell Implants as a Novel Treatment for Parkinson's Disease Jack L. Tseng and Patrick Aebischer Neural Stem Cell Technology as a Novel Treatment for Parkinson's Disease Richard J. E. Armstrong, Anne E. Rosser, Stephen B. Dunnett, and Roger A. Barker
- Kurztext
- The use of molecular technologies to study Parkinson's disease in the laboratory is beginning to have a major impact in clinical medicine. In Parkinson's Disease: Methods and Protocols, internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson's disease and basal ganglia function, adding along the way considerable background information about the rationale and utility of these methods, as well as about fundamental issues in Parkinson's disease. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigrostriatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells. Comprehensive and timely, Parkinson's Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson's and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics.