Detailansicht
Metal-Based Neurodegeneration
eBook - From Molecular Mechanisms to Therapeutic Strategies
ISBN/EAN: 9781118553497
Umbreit-Nr.: 5621799
Sprache:
Englisch
Umfang: 440 S., 44.87 MB
Format in cm:
Einband:
Keine Angabe
Erschienen am 04.09.2013
Auflage: 2/2013
E-Book
Format: PDF
DRM: Adobe DRM
- Zusatztext
- <p>Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.</p><p><i>Metal-based Neurodegeneration</i> presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides.</p><p>Topics covered include:</p><ul><li>Brain function, physiology and the blood-brain barrier</li><li>Immune system and neuroinflammation</li><li>Aging and mild cognitive impairment, MCI</li><li>Parkinsons Disease</li><li>Alzheimers Disease</li><li>Creutzfelt-Jakob and related prion diseases</li><li>Alcoholic Brain Damage</li><li>Therapeutic strategies to combat the onset and progression of neurological diseases</li></ul><p>This extensively updated, full colour, second edition of<i>Metal-based Neurodegeneration</i> is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.</p>
- Kurztext
- Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson s Disease Alzheimer s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
- Autorenportrait
- <b>Robert Crichton and Roberta Ward,</b><br /> Unit of Biochemistry, Université Catholique de Louvain, Belgium