Detailansicht
Drug Absorption Studies
In Situ, In Vitro and Silico Models - Biotechnology: Pharmaceutical Aspects VII, Biotechnology: Pharmaceutical Aspects VII
ISBN/EAN: 9780387749006
Umbreit-Nr.: 1210234
Sprache:
Englisch
Umfang: xxii, 696 S.
Format in cm:
Einband:
gebundenes Buch
Erschienen am 18.01.2008
Auflage: 1/2008
- Zusatztext
- InhaltsangabePerfused Organ Level/In Situ Techniques.- Models for Skin Absorption and Skin Toxicity Testing.- Models of the Small Intestine.- Drug Absorption from the Colon In Situ.- In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa.- In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies.- The Isolated Perfused Lung for Drug Absorption Studies.- Cellular Level-In Vitro Models of Epithelial and Endothelial Barriers.- In Vitro Models for Investigations of Buccal Drug Permeation and Metabolism.- In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism.- In Vitro Cellular Models for Nasal Drug Absorption Studies.- In Vitro Models of the Tracheo-Bronchial Epithelium.- In Vitro Models of the Alveolar Epithelial Barrier.- Cell Culture Models of the Corneal Epithelium and Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies.- The Conjunctival Barrier in Ocular Drug Delivery.- Inner Blood-Retinal Barrier: Transport Biology and Methodology.- Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epithelia.- In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier.- In Vitro Models to Study Blood-Brain Barrier Function.- High-Throughput Screening Using Caco-2 Cell and PAMPA Systems.- Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations.- Bioinformatics-In Silico Tools to Predict Drug Absorption.- Modeling Transdermal Absorption.- Physiologically Based in Silico Models for the Prediction of Oral Drug Absorption.- In Silico Modeling for Blood-Brain Barrier Permeability Predictions.- Molecular/Sub-Cellular Level-Mechanistic Tools.- Impact of Drug Transport Proteins.- Cloning and Functional Heterologous Expression of Transporters.- The Pharmacology of Caveolae.- Immortalization Strategies for Epithelial Cells in Primary Culture.- Binding-Uptake Studies and Cellular Targeting.- Regulatory Considerations.- Drug Permeability Studies in Regulatory Biowaiver Applications.
- Kurztext
- Comprehensively summarises the different approaches to assess drug absorption from in vitro modelsGives a review on the current state-of-the-art in pharmaceutical cell biologyProvides readers with helpful protocols for many applications that can be directly used at the laboratory bench