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High Throughput Analysis for Food Safety
Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications
ISBN/EAN: 9781118396308
Umbreit-Nr.: 7139601
Sprache:
Englisch
Umfang: 298 S.
Format in cm:
Einband:
gebundenes Buch
Erschienen am 17.10.2014
Auflage: 1/2014
- Zusatztext
- This book focuses on high-throughput analyses for food safety. Because of the contributors domestic and international expertise from industry and government the book appeals to a wider audience. It includes the latest development in rapid screening, with a particular emphasis on the growing use and applicability of a variety of stand-alone mass spectrometry methods as well as using mass spectrometry in hyphenated techniques such as gas chromatograph mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS). Readers will be educated to the field of food safety and rapid testing in the most commonly used techniques. Divided into three parts (Basics of High Throughput Analyses, Mass Spectrometry in High Throughput Analyses, and International Food Safety Testing) this book covers many important aspects of high-throughput analyses for food safety.
- Autorenportrait
- InhaltsangabePREFACE xi CONTRIBUTORS xiii CHAPTER 1 INTRODUCTION: BASIC PRINCIPLES OF ASSAYS TO BE COVERED, SAMPLE HANDLING, AND SAMPLE PROCESSING 1 Wanlong Zhou, Eugene Y. Chang, and Perry G. Wang 1.1 Introduction 1 1.1.1 Current Situation and Challenges of Food Safety and Regulations 1 1.1.2 Residues and Matrices of Food Analysis and High-Throughput Analysis 2 1.1.3 Food Safety Classifications 3 1.1.4 "High Throughput" Definition 3 1.1.5 Scope of the Book 4 1.2 Advanced Sample Preparation Techniques 5 1.2.1 Automation of Weighing and Preparing Standard Solutions 5 1.2.2 QuEChERS 6 1.2.3 Swedish Extraction Technique (SweEt) and Other Fast Sample Preparation Methods 6 1.2.4 Turbulent Flow Chromatography 7 1.2.5 Pressurized Liquid Extraction 7 1.2.6 Automated 96- and 384-Well Formatted Sample Preparation as well as Automated SPE Workstations 8 1.2.7 SolidPhase Microextraction 8 1.2.8 Microextraction by Packed Sorbent 9 1.2.9 Liquid Extraction Surface Analysis 9 1.2.10 Headspace GC 10 1.2.11 Summary 10 1.3 Future Perspectives 10 Acknowledgment 11 References 11 CHAPTER 2 SURVEY OF MASS SPECTROMETRY-BASED HIGH-THROUGHPUT METHODS IN FOOD ANALYSIS 15 Lukas Vaclavik, Tomas Cajka, Wanlong Zhou, and Perry G. Wang 2.1 Introduction 15 2.2 Techniques Employing Chromatographic Separation 15 2.2.1 Gas Chromatography-Mass Spectrometry 15 2.2.2 Liquid Chromatography-Mass Spectrometry 21 2.3 Direct Techniques 30 2.3.1 MatrixAssisted Laser Desorption/IonizationMass Spectrometry 30 2.3.2 Headspace (Solid-Phase Microextraction)-Mass Spectrometry E-Nose 37 2.3.3 Ambient Desorption/Ionization-Mass Spectrometry 38 2.4 Concluding Remarks 62 Acknowledgments 62 References 63 CHAPTER 3 QUALITY SYSTEMS, QUALITY CONTROL GUIDELINES AND STANDARDS, METHOD VALIDATION, AND ONGOING ANALYTICAL QUALITY CONTROL 73 David Galsworthy and Stewart Reynolds 3.1 Introduction 73 3.1.1 Quality System Design 73 3.1.2 Procedures 74 3.1.3 Roles and Responsibilities 74 3.1.4 Quality Manual 74 3.1.5 Document Control 74 3.1.6 Control of Records 75 3.1.7 Audits 75 3.1.8 Validation of Methodology 75 3.1.9 Staff Competency 75 3.1.10 Internal Quality Control 76 3.1.11 Method Performance Criteria 76 3.2 Qualitative Screening Methods 76 3.2.1 Selectivity of Mass Spectrometry-Based Methods 78 3.2.2 Confirmatory Methods 78 3.2.3 Validation of Qualitative Screening Multiresidue Methods for Pesticide Residues in Foods 79 3.3 Elements of the Analytical Workflow 80 3.3.1 Sample Preparation 80 3.3.2 Effects of Sample Processing 81 3.3.3 Extraction Efficiency 81 3.4 Initial Method Validation 81 3.5 Ongoing Analytical Quality Control 86 3.5.1 Internal Quality Control 86 3.5.2 Proficiency Testing 86 3.6 Validation of Qualitative Screening Multiresidue Methods for Veterinary Drug Residues in Foods 87 3.6.1 EU Legislation Covering Method Validation for Veterinary Drug Screening 87 3.6.2 Determination of Specificity/Selectivity and Detection Capability (CCß) Using the Classical Approach 88 3.6.3 Establishment of a Cutoff Level and Calculation of CCß 88 3.6.4 Determination of the Applicability 89 3.7 Conclusions 90 References 90 CHAPTER 4 DELIBERATE CHEMICAL CONTAMINATION AND PROCESSING CONTAMINATION 93 Stephen Lock 4.1 Introduction 93 4.2 HeatInduced Food Processing Contaminants 97 4.3 Packaging Migrants 101 4.4 Malicious Contamination of Food 105 References 111 CHAPTER 5 MULTIRESIDUAL DETERMINATION OF 295 PESTICIDES AND CHEMICAL POLLUTANTS IN ANIMAL FAT BY GEL PERMEATION CHROMATOGRAPHY (GPC) CLEANUP COUPLED WITH GC-MS/MS, GC-NCI-MS, AND LC-MS/MS 117 YanZhong Cao, YongMing Liu, Na Wang, XinXin Ji, CuiCui Yao, Xiang Li, LiLi Shi, QiaoYing Chang, ChunLin Fan, and GuoFang Pang 5.1 Introduction 117 5.1.1 Persistent Organic Pollutants 118 5.1.2 Polycyclic Aromatic Hydroc