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Molecular Aspects of Oxidative Drug Metabolizing Enzymes
Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health, Nato ASI Series (closed) 90, Nato ASI Subseries H: 90
ISBN/EAN: 9783642795305
Umbreit-Nr.: 4379863
Sprache:
Englisch
Umfang: ix, 614 S., 10 s/w Illustr., 614 p. 10 illus.
Format in cm:
Einband:
kartoniertes Buch
Erschienen am 13.12.2011
Auflage: 1/1995
- Zusatztext
- Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.
- Kurztext
- Proceedings of the NATO Advanced Study Institute on molecular aspects of drug metabolizing enzymes, held in Kusadasi, Aydin-Turkey, June 20-July 2, 1993