Detailansicht
Molecular and Cellular Biology of Neuroprotection in the CNS
Advances in Experimental Medicine and Biology 513
ISBN/EAN: 9780306474149
Umbreit-Nr.: 1536777
Sprache:
Englisch
Umfang: xvii, 501 S.
Format in cm:
Einband:
gebundenes Buch
Erschienen am 31.01.2003
- Zusatztext
- InhaltsangabeI: Neuronal Cell Death - Overview of Basic Mechanisms. 1. Excitatory amino acid neurotoxicity; T. Gillessen, et al. 2. Neuronal survival and cell death signaling pathways; R.S. Morrison, et al. 3. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system; G. Stoll. 4. Cellular and molecular determinants of glial scar formation; A. Logan, M. Berry. II: Ion Channels, Receptors and Signaling Pathways. 5. Na+ channels and Ca2+ channels of the cell membrane as targets of neuroprotective substances; C. Alzheimer. 6. Intracellular Ca2+ handling; R.J. Sayer. 7. Neuroprotective activity of metabotropic glutamate receptor ligands; P.J. Flor, et al. 8. A role for glutamate transporters in neurodegenerative diseases; D. Trotti. 9. Purines and neuroprotection; T.W. Stone. 10. Heat shock proteins and neuroprotection; M.A. Yenari. III: Neurotrophic Factors as Neuroprotective Agents. 11. Neurotrophins; G. Dechantl, H. Neumann. 12. Fibroblast growth factors and neuroprotection; C. Alzheimer, S. Werner. 13. TGF-betas and their roles in the regulation of neuron survival; K. Unsicker, K. Krieglstein. 14. Vascular endothelial growth factor; H.H. Marti. IV: Advances in Drug Delivery to CNS Neurons. 15. Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins; W.M. Pardridge. 16. Invasive drug delivery; U. Blömer, et al. V: Neuroprotective strategies in animal and in vitro models of neuronal damage. 17. Ischemia and stroke; M. Endres, U. Dirnagl. 18. Neuroprotective strategies in Alzheimer's disease; C. Behl. Index.
- Kurztext
- Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight this field.