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Cortico-Subcortical Dynamics in Parkinson's Disease
eBook - Contemporary Neuroscience
ISBN/EAN: 9781603272520
Umbreit-Nr.: 1796395
Sprache:
Englisch
Umfang: 316 S., 7.66 MB
Format in cm:
Einband:
Keine Angabe
Erschienen am 20.04.2009
Auflage: 1/2009
E-Book
Format: PDF
DRM: Digitales Wasserzeichen
- Zusatztext
- The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the inputoutput operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [35]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.
- Kurztext
- <P>This book assembles all that is currently known about the pathophysiological changes underlying Parkinsons Disease (PD). It integrates key aspects of current PD knowledge and research, and provides critical reviews about mechanisms of neurodegeneration.</P>