Detailansicht
The Histone Code and Beyond
New Approaches to Cancer Therapy, Ernst Schering Foundation Symposium Proceedings 57
ISBN/EAN: 9783642421754
Umbreit-Nr.: 7807387
Sprache:
Englisch
Umfang: xiv, 215 S.
Format in cm:
Einband:
kartoniertes Buch
Erschienen am 27.11.2014
Auflage: 1/2014
€ 106,99
(inklusive MwSt.)
Nachfragen
- Zusatztext
- Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.